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4YX9 CFTR Inhibitory Factor Cif Cartoon Visual The alpha helices in pink and beta sheets shown in yellow make up the secondary structures. Regions that are without secondary structures are white.Cif is composed of 42% helical structures (17 helices) and 19% beta sheets (13 beta strands). It has a binding site residue 4HY known as [4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-Acetic Acid. Inhibiting an Epoxide Hydrolase Virulence Factor from
Pseudomonas aeruginosa Protects CFTR. Bahl, C.D., Hvorecny,
K.L., Bomberger, J.M., Stanton, B.A., Hammock, B.D., Morisseau,
C., Madden, D.R. 4YX9 (PDB) |
4YX9 CFTR Inhibitory Factor Cif CPK Visual The alpha helices in pink and beta sheets shown in yellow make up the secondary structures. Regions that are without secondary structures are white. Cif is an epoxide hydrolase (EH) with a non-canonical active site. From comparisons of other structures, Cif as an enzyme uses a catalytic triad of residues Asp129, Glu153 and His297, with accessory residues His177 and Tyr239 coordinating the epoxide oxygen during ring opening.Cif is delivered into the cytoplasm of human airway epithelial cells. It then blocks the post-endocytic deubiquitination of CFTR,6 thereby inducing a rapid drop in apical CFTR and chloride-secretion levels. Which leads to phenocopying key aspects of CF Inhibiting an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa Protects CFTR. Bahl, C.D., Hvorecny, K.L., Bomberger, J.M., Stanton, B.A., Hammock, B.D., Morisseau, C., Madden, D.R. (PubMed) 4YX9 (PDB) Back to ToC |